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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
18.18
Human Site:
S541
Identified Species:
28.57
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S541
N
Y
S
K
Y
L
L
S
L
K
E
K
E
E
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S541
N
Y
S
K
Y
L
L
S
L
K
E
K
E
E
D
Dog
Lupus familis
XP_531814
1283
145094
Q515
V
A
H
Y
P
P
V
Q
V
L
F
E
K
G
N
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S540
N
Y
S
R
Y
L
L
S
L
K
E
K
E
E
E
Rat
Rattus norvegicus
XP_002726765
1361
151628
S543
N
Y
S
R
Y
L
L
S
L
K
E
K
E
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
L647
T
E
N
H
N
K
Y
L
L
C
V
K
E
K
E
Frog
Xenopus laevis
NP_001089247
1340
149481
C520
S
H
S
K
Y
L
L
C
F
K
E
K
M
D
D
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
S540
T
Q
S
K
Y
L
L
S
I
K
E
K
S
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
L436
N
C
S
R
L
L
T
L
V
S
H
H
M
P
V
Honey Bee
Apis mellifera
XP_392346
1120
127429
N366
E
K
C
P
S
G
S
N
I
S
H
Y
G
V
C
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
L432
Y
R
S
Q
L
R
T
L
L
A
N
V
I
V
V
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
Q513
R
Y
S
E
T
L
I
Q
K
G
Y
R
I
A
R
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
N522
H
T
R
N
P
L
V
N
E
L
A
P
L
S
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
G514
L
M
A
L
T
E
G
G
E
S
L
T
N
P
T
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
S488
M
L
E
F
E
D
D
S
E
C
T
K
L
D
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
0
N.A.
86.6
93.3
N.A.
N.A.
20
60
66.6
N.A.
20
0
13.3
20
P-Site Similarity:
100
N.A.
100
33.3
N.A.
100
100
N.A.
N.A.
40
80
80
N.A.
33.3
13.3
20
40
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
0
0
0
0
0
7
7
0
0
7
0
% A
% Cys:
0
7
7
0
0
0
0
7
0
14
0
0
0
0
7
% C
% Asp:
0
0
0
0
0
7
7
0
0
0
0
0
0
14
27
% D
% Glu:
7
7
7
7
7
7
0
0
20
0
40
7
34
34
27
% E
% Phe:
0
0
0
7
0
0
0
0
7
0
7
0
0
0
0
% F
% Gly:
0
0
0
0
0
7
7
7
0
7
0
0
7
7
0
% G
% His:
7
7
7
7
0
0
0
0
0
0
14
7
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
14
0
0
0
14
0
0
% I
% Lys:
0
7
0
27
0
7
0
0
7
40
0
54
7
7
0
% K
% Leu:
7
7
0
7
14
60
40
20
40
14
7
0
14
0
0
% L
% Met:
7
7
0
0
0
0
0
0
0
0
0
0
14
0
0
% M
% Asn:
34
0
7
7
7
0
0
14
0
0
7
0
7
0
7
% N
% Pro:
0
0
0
7
14
7
0
0
0
0
0
7
0
14
0
% P
% Gln:
0
7
0
7
0
0
0
14
0
0
0
0
0
0
0
% Q
% Arg:
7
7
7
20
0
7
0
0
0
0
0
7
0
0
7
% R
% Ser:
7
0
60
0
7
0
7
40
0
20
0
0
7
7
0
% S
% Thr:
14
7
0
0
14
0
14
0
0
0
7
7
0
0
14
% T
% Val:
7
0
0
0
0
0
14
0
14
0
7
7
0
14
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
34
0
7
40
0
7
0
0
0
7
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _